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Are you ready? 🤓 Acemannan is the bioactive polysaccharide found in the inner gel of Aloe vera, but it’s extremely delicate; heat, oxygen, and time all degrade it. Once the gel is exposed to air or processed incorrectly, the long sugar chains that make it biologically active begin to break down into simple sugars that lose their immune-modulating function. To actually get active acemannan, the aloe must be harvested from mature leaves (usually 3 years old) and processed within hours using cold,