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Spinal muscular atrophy (SMA) types 1 through 4 all result from a single known cause — a deficiency of a protein called SMN, which stands for " survival of motor neuron." Deficiency of SMN protein occurs …

The SMN protein is found throughout the body, with highest levels in the spinal cord. This protein is one of a group of proteins called the SMN complex, which is important for the maintenance of specialized …

Due to a mutation in the survival motor neuron gene 1 (SMN1), individuals with SMA do not produce survival motor neuron (SMN) protein at high enough levels. Without this protein, the motor neuron …

Jul 28, 2025 · As its name suggests, SMN protein is crucial for the survival of motor neurons. SMN’s job is to help send signals from the brain to the spinal cord and muscles, telling them to move.

Learn about the biology, genetics, and causes of SMA, and how the SMN1 gene, SMN2 gene, and SMN protein affect SMA disease.

Aug 4, 2022 · Spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by mutations in SMN1 (encoding survival motor neuron protein (SMN)). Reduced expression of SMN leads to loss of …

Feb 6, 2024 · The survival motor neuron (SMN) protein is a crucial component of the spliceosome complex and is essential for the proper function of all cell types (Mercuri et al., 2022).

Motor neurons need the survival motor neuron (SMN) protein to work correctly. In SMA, your baby’s body cannot make enough SMN protein. When a baby cannot make enough SMN protein, motor …

Nov 25, 1998 · Spinal muscular atrophy (SMA) is a common motor neuron degenerative disease that results from reduced levels of, or mutations in, the Survival of Motor Neurons (SMN) protein. SMN is …