Sep 9, 2025 · The nuclear pore complex: three-dimensional surface structure revealed by field emission, in-lens scanning electron microscopy, with underlying structure uncovered by proteolysis.

Owing to its size and complexity (~1,000 protein subunits, ~110 MDa in humans), the NPC has remained one of the foremost challenges for structure determination. Structural studies have now …

The nuclear pore complex consists predominantly of a family of proteins known as nucleoporins (Nups). Each pore complex in the human cell nucleus is composed of about 1,000 individual protein …

Jul 31, 2025 · Explore the intricate architecture of the nuclear pore complex, a vital cellular gatekeeper, and understand how its detailed structure governs essential…

Jun 1, 2025 · Structure architecture of NPC comprises five major structure modules: cytoplasmic filaments, membrane ring, two inner rings, two outer rings, as well as nuclear baskets.

Embedded throughout the nuclear envelope are large protein complexes known as nuclear pore complexes (NPCs) that sit in circular openings where the outer nuclear membrane is fused with the …

Atomic-resolution crystal structures of single nucleoporins and their subcomplexes have been determined individually, and maps of the entire NPC scaffold, detailed enough to see proteins but not …

Jun 21, 2025 · Explore the structural principles of the nuclear pore complex, examining how protein components assemble into a dynamic and symmetrical molecular machine.

Introduction The nuclear pore complex (NPC) is a eukaryotic cellular structure that regulates bidirectional traffic of macromolecules across the nuclear envelope.

Feb 1, 2023 · The nuclear pore complex (NPC) is a supra-molecular assembly that mediates substance and information flow across the nuclear envelope (NE). Due to its extraordinary size and complexity, …