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Copyright © 2026 American Society for Clinical Investigation ISSN: 0021-9738 (print), 1558-8238 (online)
JCI - Ruling in, ruling out: the clinical utility of plasma biomarkers ...
Oct 1, 2025 · Ruling in, ruling out: the clinical utility of plasma biomarkers in diagnosis of Alzheimer’s disease Julie K. Wisch and Beau M. Ances
JCI - The gut microbiome and cancer response to immune checkpoint ...
Feb 3, 2025 · The field of the microbiome and immunotherapy has skyrocketed since 2015 when two studies demonstrated a fascinating phenomenon in mice: certain gut bacteria could enhance the …
JCI - The science of safety: adverse effects of GLP-1 receptor agonists ...
Feb 16, 2026 · View this article via: JCI CrossRef PubMed Google Scholar Mentis N, et al. GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes.
JCI - Reinvigorating drug development around NGF signaling for pain
Feb 17, 2025 · In this issue of the JCI, Peach et al. take a major step forward in this area by deciphering complexities in the signaling of the NGF receptor TrkA, finding that neuropilin 1 (NRP1) acted as a …
JCI - Mechanisms and clinical implications of gut-brain interactions
Jan 2, 2026 · View this article via: JCI CrossRef PubMed Google Scholar Bauer IJ, et al. Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging.
JCI - The promise of GLP-1 receptor agonists for neurodegenerative …
Feb 16, 2026 · View this article via: JCI CrossRef PubMed Google Scholar Aviles-Olmos I, et al. Motor and cognitive advantages persist 12 months after exenatide exposure in Parkinson’s disease.
JCI - Antiinflammatory actions of glucagon-like peptide-1–based ...
Nov 3, 2025 · View this article via: JCI Insight CrossRef PubMed Google Scholar Trevaskis JL, et al. Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological …
JCI - Disrupted minor intron splicing activates reductive carboxylation ...
Mar 18, 2025 · Aberrant RNA splicing is tightly linked to diseases, including metabolic dysfunction–associated steatotic liver disease (MASLD). In this study, we revealed that minor intron …
JCI - Allergen-specific mRNA–lipid nanoparticle therapy for prevention ...
Sep 23, 2025 · Allergic diseases have reached epidemic proportions globally, calling attention to the need for better treatment and preventive approaches. Herein, we developed allergen-encoding …