A spectrogram of brain rhythm frequencies over time predicted by the team's model. After a first, moderate dose of ketamine gamma brain rhythm power (warmer colors) emerges. Then as the dose increases ...

Many people with major depressive disorder get no relief from current treatments. Newer combinations of existing medications might help, researchers report in JAMA Psychiatry.

UB neuroscientists have identified the binding site of low-dose ketamine, providing critical insight into how the medication, often described as a wonder drug, alleviates symptoms of major depression ...

University at Buffalo neuroscientists have identified the binding site of low-dose ketamine, providing critical insight into how the medication, often described as a wonder drug, alleviates symptoms ...

These images demonstrate the different binding sites in NMDA receptors that the UB team has discovered are responsible for ketamine’s distinct clinical effects, as an anesthetic at high doses and as ...

A new study by Canadian researchers brings us one step closer to understanding the antidepressant effects of ketamine in sub-anesthetic doses. In mice, the researchers identified how two ...

Treatment-resistant depression affects a large proportion of people with major depressive disorder, and while ketamine offers rapid relief, its antidepressant effects fade within a few weeks. Now, ...

Weill Cornell Medicine investigators have "reverse engineered" ketamine's antidepressant effects to identify potential new ...

New research addresses a gap in understanding how ketamine's impact on individual neurons leads to pervasive and profound changes in brain network function. A World Health Organization Essential ...

BUFFALO, N.Y. — University at Buffalo neuroscientists have identified the binding site of low-dose ketamine, providing critical insight into how the medication, often described as a wonder drug, ...