(a) Proposed protometabolic pentose pathway leading to the accumulation of aldonates followed by nonselective oxidation to uronates, carbonyl migration, and β-decarboxylation. (b) First few steps of ...
Kishimoto and colleagues found that the degradative effect of IMiDs on IKZF1 and CK-1α, as well as upregulation of IL-2, is dependent on the CRBN-IMiD binding region. Therefore, the anti-inflammatory ...
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