NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...

Non-V600 mutations comprise approximately 35% of all BRAF mutations in cancer. Many of these mutations have been identified as oncogenic drivers and can be classified into three classes according to ...

F. Donelson Smith, Mitchell H. Omar, Patrick J. Nygren, Joseph Soughayer, Naoto Hoshi, Ho-Tak Lau, Calvin G. Snyder, Tess C. Branon, Debapriya Ghosh, Lorene K ...

If cells are the factories, proteins are the workers. They control nearly every aspect of cell function, from structure to signaling, from transport to defense. And, like many workers, they rarely act ...

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its ...

The startup is developing a medicine that can very specifically degrade cancerous forms of EGFR, the target of an array of ...

A comprehensive mini-review published today after peer review in Brain Medicine by Dr. Tao Ma and colleagues at Wake Forest ...