Skeletal muscle is the type of muscle that controls movement. Problems with these muscles can be minor, life-threatening, or ongoing problems that make it hard to perform basic daily activities.

Because RyR1 is also expressed in neurons, immune cells, and vascular smooth muscle, the E3896A model offers a unique tool to examine CICR's broader physiological roles. By combining gene engineering, ...

The heart pumps blood through the vascular system, supplying cells with oxygen and energy Smooth muscle cells in the vessels finely regulate the blood flow. If they cannot perform their task, ...

The muscular system works to control the movement of our body and internal organs. Muscle tissue contains something called muscle fibers. Muscle fibers consist of a single muscle cell. They help to ...

Smooth muscle differentiation is induced in the embryonic bladder by the centrally located urothelium in the undifferentiated mesenchyme in the periphery adjacent to the serosa. We hypothesize that ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...