Gene therapy vectors based on gamma-retroviruses, lentiviruses and adeno-associated virus integrate into the genome of transduced cells with different efficiency and integration site selection 1,2,3,4 ...
The human adenoviruses (Ads) comprise a group of 51 serologically distinct viruses. 1, 2 Among them, Ad vectors widely used for gene therapy are based on Ad serotype 5 (Ad5), which belongs to subgroup ...
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