Immune system disorders in children can involve an underactive, overactive, or misdirected immune response. Main groups include immunodeficiencies, autoimmune diseases, atopic diseases, and ...

Scientists have pinpointed genetic changes that can leave children born with little to no immune defence against infection. In a new study of 11 affected individuals, researchers from Newcastle ...

Inborn errors of immunity, historically termed primary immunodeficiency disorders, encompass a diverse group of heritable conditions that compromise innate and adaptive immune function. These ...

Scientists have pinpointed genetic changes that can leave children born with little to no immune defense against infection. In a new study of 11 affected individuals, researchers from Newcastle ...

New research from large population studies provides invaluable evidence on genome screening of newborn babies to reduce risks from overdiagnosis. The authors conclude that further studies are needed ...

Genomic integrity in lymphocytes relies on precise repair of DNA double-strand breaks (DSBs) introduced during antigen-receptor gene assembly and by exogenous insults. The non-homologous end joining ...

Given the heterogeneity and rarity of inborn errors of immunity (IEIs), management guidelines that deal with primary immunodeficiency as a whole are rare. The most recent general guideline, the ...

Primary immunodeficiency can increase your risk of many other health issues, so managing it is key to staying healthy. See how well you’re doing, and get simple steps for improving your immunity. It's ...

Severe Combined Immunodeficiency (SCID) is the name for a group of inherited disorders that cause babies to be born without a working immune system. These disorders are also called primary immune ...

Treatment with Xolremdi also results in a 60% reduction in the annualized infection rate compared with placebo-treated patients. The company has set a wholesale acquisition cost for Xolremdi annually ...

Exercise can take extra planning and extra precautions when you’re living with primary immunodeficiency (PI), a group of more than 400 disorders. In people with PI, the immune system is weakened or ...

Researchers have identified the genetic basis behind certain severe immunodeficiencies in newborns, paving the way for potential screening and emerging therapies. The findings, published today (24 May ...