Here we have designed and synthesized ligands that specifically bind with high affinity (K d = 53 nM) to the guanine (G)–guanine mismatch, one of four types of single-nucleotide polymorphism (SNP).

Recently, carbon-based catalysts—especially nitrogen-doped nanocarbons—have emerged as sustainable, reliable alternatives to the metal catalysts traditionally used to support chemical reactions.

cyclic AMP and cyclic GMP are universal second messengers and are sensed by receptor proteins that contain cyclic nucleotide binding (CNB) domains. In mammal, CNB domains are found in protein kinase A ...