Synapses are organized into nanocolumns that control synaptic transmission efficacy through precise alignment of postsynaptic neurotransmitter receptors and presynaptic release sites. Recent evidence ...

The neotenous, or delayed, development of primate neurons, particularly human ones, is thought to underlie primate-specific abilities like cognition. We tested whether synaptic development follows ...

A researcher at the University of Basel, in collaboration with a colleague in Austria, has developed a new model that provides a holistic view on how our brain manages to learn quickly and forms ...

In this study published in Molecular Psychiatry, researchers generated and analyzed Rp58 heterozygous mice as a model of RP58/ZBTB18 haploinsufficiency and were able to clarify the following four ...

Using a mouse model, researchers have discovered a new daily rhythm in a type of synapse that dampens brain activity. Known as inhibitory synapses, these neural connections are rebalanced so that we ...

Astrocytes are notoriously two-faced—calmly coddling neurons one minute, then ruthlessly consuming their synapses the next. Why these dramatic mood swings? Blame the EphA4 receptor, according to a ...

Co-written with Jai Liester. Silent synapses represent one of neuroscience's most fascinating discoveries—connections between neurons that lie dormant until activated by specific triggers. These ...

One of society’s greatest medical challenges is to understand and develop effective treatments for disorders of intellectual disability (ID). Around 2–3 percent of the global population meet the ...

BIN1, a late-onset Alzheimer’s disease (LOAD) genetic risk factor, is involved in many cellular phenomena, including vesicular trafficking and tau production. Now, in the August 26 Cell Reports, ...

Co-written with Jai Liester. Silent synapses represent one of neuroscience's most fascinating discoveries—connections between neurons that lie dormant until activated by specific triggers. These ...

A researcher has developed a new model that provides a holistic view on how our brain manages to learn quickly and forms stable, long-lasting memories. Their study sheds light on the crucial role of ...