As people live longer, the gut quietly accumulates damage that can tip the balance between healthy tissue renewal and chronic ...

The method developed by IBEC's Biomimetic Systems for Cell Engineering group is based on the imprinting of defined patterns of key proteins, such as Wnt3a and EphrinB1, onto a basement membrane. These ...

Your gut is a wondrous place. A special layer of cells that coats the insides of your small and large intestines takes in nutrients and water from what you ate while keeping anything bad out of your ...

In a recent study, FMI researchers have shed light on how intestinal organoids form crypts, the pockets that house stem cells for gut regeneration and long-term stability. Their findings may have ...

Lymphatic capillaries are key to mediating stem cell differentiation in the intestines, and researchers find they produce key proteins to control this mechanism. Epithelial stem cells in the intestine ...

The epithelial lining of our intestine is organized in a crypt-villi architecture and serves many essential functions including maintenance of barrier, digestion and nutrient absorption. Due to the ...

The study, “A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts,” was published in Immunity. The team, led by Carlene L. Zindl, Ph.D., found that IL-22 ...

An international team of scientists based in the Netherlands, and in China, has found that intestinal cells can change specializations during their lives, driven by the BMP signaling pathway, an ...

During drug development, researchers need to perform adequate nonclinical testing to ensure a drug’s safety and efficacy before starting clinical trials. An important aspect they must evaluate is a ...

Scientists have uncovered a gut-specific epigenetic aging mechanism that links inflammation and iron imbalance to cancer risk ...