A research group at the Stowers Institute for Medical Research says it has put to rest the notion that a gene promoter is only a promoter. They report, in the current issue of eLife Sciences, that ...

In gene therapy, promoters act as vital “on/off” switches, dictating whether a therapeutic gene is active and to what extent. While delivery vehicles such as adeno-associated viruses (AAVs) can bring ...

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a number of ...

High-resolution imaging shows how MraZ breaks and deforms to attach to repeated DNA sequences, activating the gene cluster ...

For decades, biologists have known that the instructions for life are written in DNA, yet the vast majority of those letters seemed to sit in the dark, doing little that was obvious. Now a new ...

A research team led by UAB researcher David Reverter has discovered the molecular mechanism that describes in detail the process regulating cell division in bacteria, based on the binding of the MraZ ...

Researchers say the deep learning model may help to create leads for new cancer diagnostics, patient stratification, and future therapies.

DNA can also be demethylated, either through passive or active processes. Passive DNA demethylation occurs when the methylation pattern is not replenished during DNA replication and gradually ...

Over the past two decades, researchers have learned that DNA inside the cell nucleus naturally folds into a network of ...