The CD40–CD40 ligand (CD40L) interaction is key to the maturation of functional T and B cells. To inhibit this interaction in the context of autoimmunity, Karnell and colleagues generated a ...

Predictors of Specialized Pediatric Palliative Care Involvement and Impact on Patterns of End-of-Life Care in Children With Cancer Endothelial vulnerability is a potential risk factor for ...

IRVINE, Calif.--(BUSINESS WIRE)-- Novus Therapeutics, Inc. (“Novus”) (NASDAQ: NVUS), a clinical stage biopharmaceutical company focused on developing life-changing, targeted medicines for patients ...

Subacute cutaneous lupus erythematosus (SCLE), an autoimmune-mediated disease that is characterized by widespread hardening of the skin, is triggered by various environmental factors, including ...

Antibodies to the CD40 ligand have modulated the immune system in animal experiments and in human clinical trials. Assumptions about how these antibodies work are now reexamined. It is now 50 years ...

CHATHAM, N.J., Oct. 14, 2025 (GLOBE NEWSWIRE) -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP) (“Tonix” or the “Company”), a fully integrated biotechnology company with marketed products and a ...

Please provide your email address to receive an email when new articles are posted on . Disease activity in relapsing MS patients significantly fell following treatment with frexalimab, a novel second ...

CHATHAM, N.J., Nov. 04, 2025 (GLOBE NEWSWIRE) -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP) (“Tonix” or the “Company”), a fully-integrated, commercial biotechnology company, today announced a ...

Frexalimab, an investigational second-generation CD40 ligand (CD40L) inhibitor, led to fewer new gadolinium-enhancing T1-weighted lesions in relapsing multiple sclerosis (MS), a phase II trial showed.

The CD40–CD40L costimulatory pathway regulates adaptive and innate immune responses and has been implicated in the pathogenesis of multiple sclerosis. Frexalimab is a second-generation anti-CD40L ...

After sifting through nearly 500 biological pathways, almost a dozen kinds of tissues from 100 mice, and some weighty statistical scores, the research team at the Amyotrophic Lateral Sclerosis Therapy ...

Predictors of Specialized Pediatric Palliative Care Involvement and Impact on Patterns of End-of-Life Care in Children With Cancer Three CD40L SNPs (rs3092920, rs3092952, rs3092936) were analyzed for ...