Actin, traditionally associated with the cytoskeleton, also assembles within the nucleus in response to developmental cues, stress and signalling pathways. Nuclear actin exists in monomeric (G-actin) ...

A tiny chemical modification on one of the most abundant and important proteins in cells, actin, has long been somewhat mysterious, its function not fully understood, but scientists from the Perelman ...

Our skin and mucous membranes are protected by epithelial cells. This barrier tissue performs its function thanks to specialized structures called junctions. They ensure cell cohesion and regulate ...

Over the last several years the identification and functional characterization of the motor proteins actin and myosin in the nucleus has initiated a change in the view of nuclear processes. It is now ...

Cellular motility is orchestrated by the dynamic assembly and disassembly of actin filaments coupled to the force-generating activity of myosin motors. Globular actin (G-actin) polymerises into ...

Tiny things matter – for instance, one amino acid can completely alter the architecture of the cell. Researchers at the Universities of Göttingen and Warwick investigated the structure and mechanics ...

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin. The actin filament is a double-stranded helical structure ...

Cells are characterized to be stable yet highly flexible. They constantly modify their shape and even move through tissue. These vital properties are based on a dynamically organized network of ...