News Medical

Understanding the platelet-monocyte interaction to improve treatment of immune disorders

Monocytes, a special type of white blood cell, secrete cytokines as inflammatory messengers that are crucial for an appropriate immune response. Researchers at the University Hospital Bonn (UKB) and ...
ALZFORUM

Circulating Monocytes Replace Microglia, Border-Associated Macrophages

Brain macrophages serve diversified niches in the brain to maintain the organ’s homeostasis, and can play pathogenic roles in age-related brain disease. Hoping to one day replace dysfunctional ...
ascopubs.org

Use of circulating and tumor-infiltrating myelomonocytic cells to predict survival in human malignant pleural mesothelioma (MPM).

Role of the type III TGF-b receptor in mediating immunosuppression during breast cancer progression. Background: MPM is a devastating cancer with limited effective therapies. Mesothelioma tumor cells ...
Fred Hutch

Misbehaving monocytes drive graft-versus-host disease

Hematopoietic cell transplantation (HCT), also known as bone marrow transplantation, is a critical treatment for blood cancers such as leukemia, lymphoma, and myeloma, as well as certain genetic and ...
ascopubs.org

A phase 1, first-in-human study of autologous monocytes engineered to express an anti-HER2 chimeric antigen receptor (CAR) in participants with HER2-overexpressing solid tumors.

DUET-01: A first-in-human, phase 1/2 study of BOXR1030 in patients with advanced glypican-3-positive solid tumors. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract ...